Dr. Md. Anwarul Azim Akhand

Akhand AA and Ahsan N "Cells and organs of the immune system." Immunology for Dentristy. Wiley, 2023 1-12 .

Nakashima I, Akhand AA, Pu M, Kato M, Hamaguchi M, Senga T, Suzuki H, Parashar A, Du J, Liu W, Umeda Y and Miyata T "Redox-oriented chemical events in signal transduction in cells." Redox Regulation of Cell Signaling and its Clinical Application. New York: Marcel Dekker, Inc., 1999 177-204 .

Fitri Kurniasari, Maw Than Htike, Akira Tazaki, Takumi Kagawa, MM Aeorangajeb Al Hossain, Anwarul Azim Akhand, Nazmul Ahsan, Shoko Ohnuma, Naruhito Iwasaki and Masashi Kato : Beneficial and adverse effects of dam construction in canal tannery wastewater effluent with a high content of chromium in Hazaribagh, Bangladesh, Chemosphere , vol.350 Elsevier , pp.141047 , 2024 .

Tomoyuki Tsuchiyama, Dijie Chen, Aeorangajeb Alhossain, Akira Tazaki, Takumi Kagawa, Yishuo Gu, Yanjun Gao, Fitri Kurniasari, Nazmul Ahsan, Anwarul Azim Akhand and Masashi Kato : Unexpected associations of long-term and excessive exposure to trivalent chromium with hypertension and glycosuria in male tannery workers., Chemosphere , pp.139190--139190 , 2023 .

Yishuo Gu, Nobutaka Ohgami, Aeorangajeb Al Hossain, Akira Tazaki, Tomoyuki Tsuchiyama, Tingchao He, Masayo Aoki, Nazmul Ahsan, Anwarul Azim Akhand and Masashi Kato : Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh, Chemosphere , vol.306 Elsevier , pp.135571 , 2022 .

Fitri Kurniasari, Akira Tazaki, Kazunori Hashimoto, Tian Yuan, Aeorangajeb Al Hossain, Anwarul Azim Akhand, Nazmul Ahsan, Shoko Ohnuma and Masashi Kato : Redistribution of potentially toxic elements in the hydrosphere after the relocation of a group of tanneries, Chemosphere , vol.303 Elsevier , pp.135098 , 2022 .

Tian Yuan, Akira Tazaki, Kazunori Hashimoto, Aeorangajeb Al Hossain, Fitri Kurniasari, Nobutaka Ohgami, Masayo Aoki, Nazmul Ahsan, Anwarul Azim Akhand and Masashi Kato : Development of an efficient remediation system with a low cost after identification of water pollutants including phenolic compounds in a tannery built-up area in Bangladesh, Chemosphere , vol.280 Elsevier , pp.130959 , 2021 .

Nazmul Hasan, Nazmul Ahsan, Ahmed Faisal Sumit, Latiful Bari and Anwarul Azim Akhand : Remedial Effects of Homeopathic Medicine in Chronic Suppurative Otitis Media-Related Complications, Bioresearch Communications-(BRC) , vol.7 , no.2 , pp.982--989 , 2021 .

Zarif Hossain, Nusrat Jahan Sanzida, Anwarul Azim Akhand and Sagir Ahmed : DNA barcoding of threatened fishes of Bangladesh, Bioresearch Communications-(BRC) , vol.7 , no.2 , pp.990--998 , 2021 .

Anindita Barua, Tamim Afrin, Anwarul Azim Akhand and Sagir Ahmed : Molecular characterization and phylogenetic analysis of crabs (Crustacea: Decapoda: Brachyura) based on mitochondrial COI and 16S rRNA genes, Conservation Genetics Resources , vol.13 , no.3 Springer , pp.291--301 , 2021 .

Nazmul Hasan, Nazmul Ahsan and Anwarul Azim Akhand : A study of three cases of removing warts using Medorrhinum and Natrum Muriaticum in combination, J Complementary Alternative Med Res , vol.11 , no.01 , pp.33--37 , 2020 .

Tomoyuki Tsuchiyama, Akira Tazaki, MM Aeorangajeb Al Hossain, Ichiro Yajima, Nazmul Ahsan, Anwarul Azim Akhand, Kazunori Hashimoto, Nobutaka Ohgami and Masashi Kato : Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries, Environmental Research , vol.188 Elsevier , pp.109770 , 2020 .

Sujan Kumar Datta, Tonmoy Saha, Nusrat Jahan Sanzida, Sumaiya Ahmed, Anwarul Azim Akhand and Sagir Ahmed : New distributional record of Hasselt’s bamboo shark Chiloscyllium hasseltii (Orectolobiformes: Hemiscylliidae) from Bangladesh waters, Thalassas: An International Journal of Marine Sciences , vol.36 Springer , pp.291--295 , 2020 .

MM Aeorangajeb Al Hossain, Ichiro Yajima, Akira Tazaki, Huadong Xu, Md Saheduzzaman, Nobutaka Ohgami, Nazmul Ahsan, Anwarul Azim Akhand and Masashi Kato : Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh, Chemosphere , vol.229 Elsevier , pp.611--617 , 2019 .

He T, Ohgami N, Li X, Yajima I, Oshino R, Kato Y, Ohgami K, Xu Huadong, Ahsan N, Akhand AA and Kato M : Epidemiological analysis of hearing loss in humans drinking tube well water with high levels of iron., Sci Report. , vol.9 , pp.9028 , 2019 .

79. Ohgami N, Li X, Yajima I, Oshino R, Ohgami K, Kato Y, Ahsan N, Akhand AA and Kato M : Manganese in toenails is associated with hearing loss at high frequencies in humans, Biomarkers. , 2018 .

Yoshinaga M, Sudo M, Ninomiya H, Akhand AA and Ahsan N, Alim MA, Khalequzzaman M, Al Hossain A, Iida M, Yajima I, Ohgami N, Kato M : A comprehensive study including monitoring, assessment of health effects and development of a remediation method for chromium pollution., Chemosphere. , vol.201 , pp.667-675. , 2018 .

81. Li X, Ohgami N, Yajima I, Xu H, Iiida M, Ohino R, Ninomiya H, Shen D, Ahsan N, Akhand AA and Kato M : Arsenic level in toenails is associated with hearing loss in humans., PLoS ONE, , vol.13 , no.7 , pp.e0198743. , 2018 .

76. Barai M, Ahsan N, Paul N, Hossain K, Rashid MA, Kato M, Ohgami N and Akhand AA : Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract. Nagoya, J. Med. Sci. , vol.79 , pp.169-179. , 2017 .

Das A, Sumit AF, Ahsan N, Kato M, Ohgami N and Akhand AA : Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose., J Otol. , 2017 .

78. Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA and Kato M : Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice., Sci. Reports. , vol.7 , no.1 , 2017 .

Ohgami N, Mitsumatsu Y, Ahsan N, Akhand AA and Li X, Iida M, Yajima I, Naito M, Wakai K, Ohnuma S and Kato M : Epidemiological analysis of the association between hearing and barium in humans., J. Expo. Sci. Environ. Epidemiol. , vol.26 , no.5 , pp.488-493. , 2016 .

Yajima I, Ahsan N, Akhand AA and Al Hossain A MM, Ohgami N, Iida M, Oshino R, Naito M, Wakai K, Kato M : Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents., J Expo Sci Environ Epidemiol. , 2016 .

Sayed S, Ahsan N, Kato M, Ohgami N, Rashid A and Akhand AA : Protectiveeffects of phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice., Nagoya J. Med. Sci. , vol.77 , pp.145-153. , 2015 .

Sumit AF, Das A, Sharmin Z, Ahsan N, Ohgami N, Kato M and Akhand AA : Cigarette smoking causes hearing impairment among Bangladeshi population., PLoS ONE. , vol.10 , no.3 , pp.e0118960. , 2015 .

72. Aktar M, Islam NN, Sumit AF, Ahsan N, Hossain S, Ahmed M and Akhand AA : Tea Extract Prevents Arsenic-mediated DNA Damage and Death of Murine Thymocytes in Vitro., Dhaka Univ. J. Pharm. Sci. , vol.14 , no.1 , pp.79-85. , 2015 .

Mahmud J, Chowdhury MK, Sami AB, Akhand AA and Ahsan N : Co-resistance to Chromium and Antibiotics in Bacteria Isolated from Tannery Wastes., Dhaka Univ. J. Pharm. Sci. , vol.14 , no.2 , pp.93-197. , 2015 .

65. Yajima I, Uemura N, Nizam S, Khalequzzaman M, Thang ND, Kumasaka MY, Akhand AA and Shekhar HU, Nakajima T, Kato M : Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells, Arch. Toxicol. , vol.86 , no.6 , pp.961-973. , 2012 .

Ahsan N, Paul N, Shamma F, Islam N and Akhand AA : Leaf extract of Syzygium cumini shows anti-vibrio activity involving DNA damage., Dhaka Univ. J. Pharm. Sci. , vol.11 , no.1 , pp.25-28. , 2012 .

Sarker RSJ, Ahsan N, Hossain K, Ghosh PK, Ahsan CR and Akhand AA : Reduction of sodium arsenite-mediated adverse effects in mice using dietary supplementation of water hyacinth (Eichornia crassipes) root powder, Avicenna J. Med. Biotechnol. , vol.4 , no.3 , pp.148-154. , 2012 .

Ahsan N and Akhand AA : CD40 does not complement the function of Epstein-Barr (Evb) latent membrane protein 1 in B cell transformation., Bangladesh J. Med. Sci. , vol.11 , no.2 , pp.112-116. , 2012 .

Sarker RSJ, Ahsan N and Akhand AA : Sodium arsenite induced systemic organ damage and changes in various blood parameters in mice., Dhaka Univ. J. Pharm. Sci. , vol.11 , no.2 , pp.169-172. , 2012 .

Islam K, Haque A, Karim R, Fajol A, Hossain E, Salam KA, Ali N, Saud ZA, Rahman M, Rahman M, Karim R, Sultana P, Hossain M, Akhand AA and Mandal A, Miyataka H, Himeno S, Hossain K. : ) Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh., Environ. Health. , vol.10 , pp.64 , 2011 .

Paul N, Akhand AA and Babu SU, Islam N and Ahsan N : Syzygium cumini leaf extract showed vibriocidal activity on selected diarrhea causing bacteria., J. Adv. Lab. Res. Biol. , vol.2 , no.3 , pp.137-142. , 2011 .

Ahsan N, Faruque K, Shamma F, Islam N and Akhand AA : Arsenic Adsorption by Bacterial Extracellular Polymeric Substances., Bangladesh J. Microbiol. , vol.28 , no.2 , pp.80-83 , 2011 .

Perveen S, Ahsan N and Akhand A A : Influence of temperature and growth regulators on wound periderm formation of potato tuber., J. Adv. Lab. Res. Biol. , vol.1 , no.2 , pp.150-156. , 2010 .

60. Ali N, Hoque MA, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek MA,, Akhand AA and Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K. : Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh., Environ. Health. , vol.9 , pp.36 , 2010 .

62. Karim MR, Haque A, Islam K, Ali N, Salam KA, Saud ZA, Hossain E, Fajol A, Akhand AA and Himeno S, Hossain K : Protective effects of the dietary supplementation of turmeric (Curcuma longa L.) on sodium arsenite-induced biochemical perturbation in mice., Bangladesh Med Res Counc Bull. , vol.36 , no.3 , pp.82-88. , 2010 .

Akter MS, Ahmed MK,, Akhand AA and Ahsan N, Islam MM, Khan MS. : Arsenic and Mercury Induce Death of Anabas testudineus (Bloch) Involving Fragmentation of Chromosomal DNA., Terrestrial & Aquatic Environ Toxicol. , pp.42-47 , 2009 .

Chowdhury MK, Ahsan N and Akhand AA : Comparative antibacterial effects of leaf extracts of Azadirachta indica and Terminalia arjuna and aggregation of bacterial proteins., J Trop Med Plants. , vol.10 , no.1 , pp.31-38. , 2009 .

Chowdhury MK, Ahsan N and Akhand AA : Leaf extracts of Azadirachta indica and Terminalia arjuna induce death of HeLa cells without DNA degradation., Dhaka Univ J Pham Sci. , vol.8 , no.1 , pp.75-79. , 2009 .

Hossain K, Kawamoto Y,, Akhand AA and Yanagishita T, Hoque A, Tsuboi H, Kato M, Nakashima I. : 1,4-butanediyl-bismethanethiosulfonate (BMTS) induces apoptosis reactive oxygen species-mediated mechanism. (2009)., J. Cell. Biochem. , vol.108 , no.5 , pp.1059-65 , 2009 .

Hasan A, Ahmed MK, Akhand AA and Ahsan N, Islam M : Toxicological Effects and Molecular Changes Due to Mercury Toxicity in Freshwater Snakehead (Channa punctatus Bloch, 1973)., Int. J. Environ. Res. , vol.4 , no.1 , pp.91-98. , 2009 .

Ahsan N and Akhand AA : Latent membrane protein 1 (LMP1) of akara strain of Epstein-Barr virus is essential for B cell transformation., Bangladesh J Med Sci. 14 (2), 112-116. , vol.14 , no.2 , pp.112-116. , 2008 .

Akter MS, Ahmed MK, Akhand AA and Islam MM : Acute toxicity of Arsenic and mercury to fresh water climbing perch, Anabas testudineus (Bloch)., World J Zool. , vol.3 , no.1 , pp.13-18. , 2008 .

Ahmed MK, Akhand AA and Hasan M, Islam M, Hasan A : Toxicity of arsenic (sodium arsenite) to fresh water spotted snakehead Channa punctatus (Bloch) on cellular death and DNA content., American-Eurasian J Agric & Environ Sci. , vol.4 , no.1 , pp.18-22. , 2008 .

Ahmed M, Nazneen S and Akhand AA : Molecular analysis of hepatitis B virus DNA and mutation status in patients under lamivudine [(-) 2’ 3’-dideoxy-3’ thiacytidine] therapy, Dhaka Univ J Pharm Sci. 4(2), 19-23. , vol.4 , no.2 , pp.19-23. , 2006 .

Tsuboi H, Hossain K, Akhand AA and Takeda K, Du J, Rifai M, Dai Y, Hayakawa A, Suzuki H, Nakashima I. : Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism., J Cell Biochem. , vol.93 , pp.162-172. , 2004 .

Hossain K,, Akhand AA and Kawamoto Y, Du J, Takeda K, Wu J, Yoshihara M, Tsuboi H, Kato M, Suzuki H Nakashima I. : Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation, Free Radic. Biol. Med. , vol.34 , pp.598-606. , 2003 .

Du J, Cai S, Akhand AA and Ma X, Tagaki Y, Miyata T, Nakashima I Nagase F. : Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal., J. Cell. Biochem. , vol.88 , pp.1235-1246. , 2003 .

Liu W, Akhand AA and Takeda K, Kawamoto Y, Itoigawa M, Kato M, Suzuki H, Ishikawa N, Nakashima I. : Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal., Cell Death Differ. , vol.10 , pp.772-781. , 2003 .

Nakashima I, Liu W, Akhand AA and Takeda K, Kawamoto Y, Kato M and Suzuki H. : 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions., Mol Aspects Med. , vol.24 , pp.231-238. , 2003 .

Suzuki H, Wu J, Hossain K Ohhata T, Du J,, Akhand AA and Hayakawa A, Kimura H, Hagiwara M, Nakashima I. : Involvement of MKK6 in TCRαβintCD69lo: a target population for apoptotic cell death in thymocytes., FASEB J. , vol.17 , pp.1538-1540. , 2003 .

Kajiguchi T, Yamamoto K, Hossain K,, Akhand AA and Nakashima I, Naoe T, Saito S Emi N : Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1. Leukemia. , vol.17 , pp.2189-2195. , 2003 .

Wu J, Suzuki H,, Akhand AA and Zhou Y, Hossain K, Nakashima I. : Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells., Cell Signal. , vol.14 , pp.509-515 , 2002 .

Kato M, Takeda K, Kawamoto Y., Iwashita T,, Akhand AA and Senga T, Yamamoto M, Sobue G, Hamaguchi M, Takahashi M, Nakashima I. : Repair by Src kinase of function-impaired RET with multiple endorcrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine, Cancer Res. , vol.62 , pp.2414-2422. , 2002 .

Nakashima I, Suzuki H, Kato M and Akhand AA. : Redox control of T-cell death., Antioxid. Redox Signal. , vol.4 , pp.353-356. , 2002 .

Nakashima I, Kato M, Akhand AA and Suzuki H, Takeda K, Hossain K, Kawamoto Y : Redox-linked signal transduction pathways for protein tyrosine kinase activation., Antioxid. and Redox Signal. , vol.4 , pp.517-531. , 2002 .

Akhand AA and Du J, Liu W, Hossain K, Miyata T, Nagase F, Kato M, Suzuki H, Nakashima I. : Redox-linked cell surface-oriented signaling for T-cell death., Antioxid. and Redox Signal., , vol.4 , pp.445-454. , 2002 .

Akhand AA and Ikeyama T, Akazawa S, Kato M, Hossain K, Takeda K, Suzuki H, Takahashi M, Nakashima I. : Evidence of both extra and intracelluar cysteine targets of protein modification for activation of Ret kinase, Biochem. Biophys. Res. Com. , vol.292, , pp.826-831. , 2002 .

Ruhul Amin AR, Machida K, Oshima K, Oo ML, Thant AA, Senga T, Matsuda S,, Akhand AA and Maeda A, Kurosaki T Hamaguchi M. : A role for SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling, Oncogene. , vol.21 , pp.8871-8878. , 2002 .

Takeuchi K, Kato M, Suzuki H, Akhand AA and Wu J, Hossain K, Miyata T, Matsumoto Y, and Nakashima I : Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death., J. Cell. Biochem. , vol.81 , pp.679-688. , 2001 .

Akhand AA and Hossain K, Mitsui H, Kato M, Miyata T, Inagi R, Du J, Takeda K, Kawamoto Y, Suzuki H, Kurokawa K, Nakashima I : Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells., Free Radic. Biol. Med. , vol.31, , pp.20-30. , 2001 .

Miyata T,, Akhand AA and Kurokawa K, Nakashima I. : Reactive carbonyl compounds as uremic toxins, Contrib. Nephrol. , vol.133, , pp.71-80. , 2001 .

Wu J, Suzuki H, Zhou Y, Liu W, Yoshihara M, Akhand AA and Hayakawa A, Takeuchi K, Hossain K, Kurosawa M, Nakashima I. : Cepharanthene activates caspase and induces apoptosis in Jurkat and K562 human leukemia cell lines., J. Cell. Biochem. , vol.82, , pp.200-214. , 2001 .

Du J, Suzuki H, Nagase F,, Akhand AA and Ma X-Y, Yokoyama T, Miyata T, Nakashima I. : Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process., Free Radic. Biol. Med. , vol.31 , pp.469-478. , 2001 .

Dai Y, Kato M, Takeda K, Kawamoto Y,, Akhand AA and Hossain K, Suzuki H, and Nakashima I. : T-cell immunity-based inhibitory effects of orally administered herbal medicine Juzen-taiho-to on the growth of primarily developed melanocytic tumors in Ret-transgenic mice., J. Invest. Dermatol. , vol.117, , pp.694-701. , 2001 .

Akhand AA and Hossain K, Kato M, Miyata T, Du J, Suzuki H, Kurokawa K, Nakashima I. : Glyoxal and methylglyoxal induce aggregation and inactivation of ERK in human endothelial cells., Free Radic. Biol. Med. , vol.31 , pp.1228-1235. , 2001 .

Kato M, Iwashita T, Takeda K, Akhand AA and Liu W, Yoshihara M Asai N, Suzuki H and Nakashima I. : Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases., Mol. Biol. Cell. , vol.11 , pp.93-101. , 2000 .

Liu W, Kato M,, Akhand AA and Hotta Y, Ishikawa N, Hayakawa A, Suzuki H, Miyata T, Kurokawa K and Nakashima I. : 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death, J. Cell Sci. , vol.113, , pp.635-641. , 2000 .

Du J, Suzuki H, Nagase F,, Akhand AA and Yokoyama T, Miyata T, Kurokawa K, and Nakashima I : Methylglyoxal induces apoptosis in Jurkat leukemia T-cells by activating c-Jun N-terminal kinase, J. Cell. Biochem. , vol.77, , pp.333-344. , 2000 .

Du J, Suzuki H, Nagase F,, Akhand AA and Yokoyama T and Nakashima I : Mercuric chloride stimulates distinct signal transduction pathways for DNA synthesis in a T cell line. CTLL-2., J. Cell. Biochem. , vol.78, , pp.500-508. , 2000 .

Kato M, Iwashita T, Akhand AA and Liu W, Takeda K, Takeuchi K, Yoshihara M, Hossain K, Wu J, Oh C, Fujitani S, Shimuzu Y, Sobajima Y, Takahashi M and Nakashima I. : Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation, Antioxidants and Redox Signal. , vol.2 , pp.841-849. , 2000 .

Hossain K, Akhand AA and Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H and Nakashima I. : Arsenite induces apoptosis of murine T lymphocytes through membrane rafts-linked signaling for activation of c-Jun amino terminal kinase (JNK)., J. Immunol. , vol.165 , pp.4290-4297. , 2000 .

Nakashima I, Kato M, Akhand AA and Du J, Liu W, Dai Y, Suzuki H, Senga T, Hamaguchi M, Iwashita T, Takahashi M, Miyata T, Hossain K, Wu J, Takeuchi K, Yoshihara M and Kawamoto Y. : Chemical reaction-mediated alternative signaling pathway in cells of the immune system., Curr. Trends Immunol. , vol.3 , pp.45-58. , 2000 .

Kato M, Liu W, Akhand AA and Hossain K, Takeda K, Takahashi M and Nakashima I : Ultraviolet radiation induces both full activation of Ret kinase and malignant melanocyte tumor promotion in RFP-RET-transgenic mice., J. Invest. Dermatol. , vol.115, , pp.1157-1158. , 2000 .

Parashar A,, Akhand AA and Rawar R, Furuno T, Nakanishi M, Kato M, Suzuki H and Nakashima I. : Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phosphorylation-linked mechanism., Free Rad. Biol. & Med. 26, 227-231. , vol.26, , pp.227-231. , 1999 .

Akhand AA and Kato M, Suzuki H, Liu W, Du J, Hamaguchi M, Miyata T, Kurokawa K and Nakashima I : Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src., J. Cell. Biochem. , vol.72, , pp.1-7. , 1999 .

Kato M, Liu W,, Akhand AA and Dai Y, Ohbayashi M, Suzuki H, Isobe K, Takahashi M and Nakashima I : Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines., Oncogene. , vol.18, , pp.837-842. , 1999 .

Liu W,, Akhand AA and Kato M, Yokoyama I, Uchida K, Miyata T, Kurokawa K and Nakashima I. : 4-Hydroxynonenal triggers epidermal growth factor receptor-linked signal pathway for growth inhibition, J. Cell Sci. , vol.112. , pp.2409-2417. , 1999 .

Akhand AA and Pu M, Senga T, Kato M, Suzuki H, Miyata T, Hamaguchi M and Nakashima I : Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr527-independent and Tyr416-linked mechanism., J. Biol. Chem. 274, 25821- 25826. , vol.274, , pp.25821- 25826. , 1999 .

Nakashima I, Akhand AA and Kato M, Du J, Liu W, Hossain K, Suzuki H, Wu J, Takeda K, and Yoshihara M. : Oxidative stress and signal transduction in the immune system., Recent Res. Devel. Immunol. , vol.1, , pp.283-296. , 1999 .

Liu W, Kato M,, Akhand AA and Hayakawa A, Takemura M, Yoshida S Suzuki H and Nakashima I : The herbal medicine sho-saiko-to inhibits the growth of malignant cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulating of cyclin dependent kinase., Int. J. Oncol , vol.12 , pp.1321-1326 , 1998 .

Akhand AA and Kato M, Suzuki H, Miyata T and Nakashima I. : Level of Hgcl2-mediated phosphorylation of intracellular proteins determines death of thymic T lymphocytes with or without DNA fragmentation., J. Cell. Biochem. , vol.71, , pp.243-253. , 1998 .

Kato M, Takahashi M, Akhand AA and Liu W, Dai Y, Shimizu S, Iwamoto T, Suzuki H and Nakashima I. : Transgenic mouse model for skin malignant melanoma., Oncogene. , vol.17 , pp.1885-1888 , 1998 .

Akhand AA and Pu M, Du J, Kato M, Suzuki H, Hamaguchi M and Nakashima I. : Magnitude of protein tyrosine phosphorylation-linked signal determines growth versus death of thymic T lymphocytes Eur., J. Immunol. , vol.27, , pp.1254-1259. , 1997 .

Nakashima I, Pu M,, Akhand AA and Kato M and Suzuki H : Chemical events in signal transduction., Immunol. Today , vol.18 , pp.362. , 1997 .

Ohkusu K, Du J, Isobe K, Yi H, Akhand AA, and Kato M, Suzuki H, Hidaka H, and Nakashima I. : Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL- lpr/lpr mice, Eur. J. Immunolc , vol.25 , pp.3180-3186. , 1997 .

Pu M,, Akhand AA, and Kato M, Koike T, Hamaguchi M, Suzuki H and Nakashima I. : Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine., J. Cell. Biochem. , vol.63, , pp.104-114. , 1996 .

Pu M,, Akhand AA and Kato M, Hamaguchi M, Koike T, Iwata H, Sabe H, Suzuki H and Nakashima I : Evidence of a novel redox linked activation mechanism for the Src Kinase which is independent of tyrosine 527-mediated regulation., Oncogene, , vol.13, , pp.2615-2622. , 1996 .

Katano Y, Pu M, Akhand AA, Hamaguchi M, Koga Y and Isobe K, Fukuda Y, Hayakawa T and Nakashima I. : Evidence of redox-linked signaling for producing a giant signal complex., J. Cell. Biochem.. , vol.57 , pp.432-439 , 1995 .

Ma L, Pu M, Yi H, Akhand AA and Ohata N, Ohkusu K, Kato M, Iwamoto T, Isobe K, Hamaguchi M and Nakashima I : Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent., J. Cell Biochem. , vol.59, , pp.33-41. , 1995 .

Ali MS, Akhand AA, Gomez PF and Islam RI : Cellulase from Humicola spp, J. Basic Microbiol. , vol.33 , pp.155-159 , 1993 .

Ali MS and Akhand AA. : Cellulose from Trichoderma isolate., J. Basic Microbiol. , vol.32 , pp.259-268. , 1992 .

Nakashima I, Pu M,, Akhand AA and Kato M "Sulfhydryl-based regulation of Src family protein tyrosine kinase for cell growth and death.." Jakarta International Cancer Conference , pp. 231-240.. 1997 .